Modern Pharmaceutics, Fifth Edition, Volume 2: Applications and Advances
Volume 2 discusses the applications and approaches in advanced drug delivery systems, including transdermal, pulmonary, and ocular routes. In addition, it describes the impact of the shift to personalized medicines in the fields of pharmaceutical biotechnology, pharmacogenomics, and nanotechnology.
DELIVERY OF DRUGS BY THE PULMONARY ROUTE - Covers the interaction between the physical chemistry of the formulations and administered particles with the anatomy of the bronchial and alveolar regions
PEDIATRIC AND GERIATRIC PHARMACEUTICS - Addresses the physiological changes, design, and production of formulations for each of these patient populations
BIOEQUIVALENCE EVALUATION - Covers how to measure the bioequivalence of the same drug in quick-release tablet, capsule, or sustained-release form, as well as branded and generic systems
TARGET-ORIENTED DELIVERY SYSTEMS - Explores the challenges of designing delivery systems that target specific sites in the body and cause fewer side effects through interaction with non-diseased tissues.
ABC Transporters and Multidrug Resistance
A comprehensive review of the most current scientific research on ABC transporters and multidrug resistance
ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as tumors, to withstand chemicals designed to target and destroy such cells. In MDR, patients who are on medication eventually develop resistance to not only the drug they are taking, but to several
different types of drugs.
Oral Delivery of Macromolecular Drugs: Barriers, Strategies and Future Trends
This comprehensive volume provides an overview on the description of the structure, the genome, normal tissue expression, physiological aspect, and mechanism of action of the ABC protein. The expert contributors explore the expression, detection, and implications of ABC proteins in hematological malignancies and solid tumors and ABC proteins and pathogenic microorganisms. This volume also explains MDR modulation through inhibition of ABC transporters and the design of inhibitors and mechanism of action. In addition, the book offers essential information on the biological and clinical aspect of multidrug resistance.
-----------------------------------------------------
Oral Delivery of Macromolecular Drugs: Barriers, Strategies and Future Trends
Recent and rapid progress in the field of biotechnology has resulted in an increasing number of novel macromolecular drugs with great promise for further advanced research and clinical application. However, the delivery of these macromolecular drugs by routes other than the parenteral route is difficult. The pipeline of macromolecular drugs derived from biotechnology presents a challenging opportunity to develop practical dosage forms that could be dosed via the oral route. Given this, the successful oral delivery of macromolecular drugs presents an enormous opportunity. Oral Delivery of Macromolecular Drugs will provide an overview of the innovative oral delivery technologies that have demonstrated success in human testing and will go on to cite the challenges, strategies, and future trends that are to be expected.
[ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط]
-----------------------------------
Pharmaceutics: The Science of Dosage Form Design
A comprehensive textbook covering the design of dosage forms and all aspects of drug delivery systems. 'Pharmaceutics' in its broadest sense is the 'art of the apothecary' or, in simple terms, pharmaceutical preparations. It remains a diverse subject in the pharmacy curriculum, encompassing design of drugs, their manufacture, and the elimination of micro-organisms from the products. This books encompasses all those areas and pays particular attention to the design of dosage forms and their manufacture.
Nanotherapeutics: Drug Delivery Concepts in Nanoscience
An important and exciting aspect in the newly developing field of nanomedicine is the use of nanoparticle drug delivery systems allowing for innovative therapeutic approaches. Due to their small size, these drug delivery systems are promising tools in therapeutic approaches such as selective or targeted drug delivery towards a specific tissue or organ, enhanced drug transport across biological barriers, and intracellular drug delivery.
This timely book provides an overview of possible therapeutic applications. The first part of the book highlights general properties of and phenomena observed with nanoparticles, and the subsequent consequences for applications in drug delivery. The second part focuses on the therapeutic approaches that are possible through the use of nanoparticles, with each chapter discussing a specific disease (e.g. diabetes, cancer, inflammation, etc.) and the relevant therapeutic approaches based on the design of nanoparticulate drug delivery systems. Written in a concise manner, readers will gain an insight into the basics of nanoparticle preparation as well as a more detailed account of what is therapeutically feasible by using nanoparticle approaches.
Contents: General Aspects of Nanotherapeutics: Nanocarriers in Drug Delivery - Design, Manufacture and Physicochemical Properties (C Schmidt & A Lamprecht); Transport Across Biological Barriers (N Nafee et al.); Targeting Approaches (S Cammas-Marion); Disease-Related Approaches by Nanotherapeutics: Nanoscale Cancer Therapeutics (Y Pellequer & A Lamprecht); Nanotherapeutics for Skin Diseases (N Atrux-Tallau et al.); Nanoparticles for Oral Vaccination (J M Irache et al.); Nanoparticles: Therapeutic Approaches for Bacterial Diseases (B Moulari); Nanoparticle Therapy in Parasites Diseases: Possibility and Reality! (M Larabi); Nanocarriers in the Therapy of Inflammatory Disease (A Lamprecht).
Physicochemical Principles of Pharmacy, 4th Edition
Physical chemistry is the basis of rational pharmaceutical formulation and processing, and is fundamental to understanding the complexities of drug delivery and drug absorption. This textbook presents the physiochemical principles useful to the modern pharmaceutical scientist and pharmacist.
Nanotechnology in Drug Delivery
The reader will be introduced to various aspects of the fundamentals of nanotechnology based drug delivery systems and the application of these systems for the delivery of small molecules, proteins, peptides, oligonucleotides and genes. How these systems overcome challenges offered by biological barriers to drug absorption and drug targeting will also be described.
Encyclopedia of Pharmaceutical Technology, Volume 20
AAI, Inc., Wilmington, NC. An encyclopedia of pharmaceutical technology, offering a collection of entries on a number of subjects, from drug delivery to process chemistry in the pharmaceutical industry. Lists the contents for all 20 volumes in the set. DNLM: Chemistry, Pharmaceutical-encyclopedias.
Electrically Assisted Transdermal and Topical Drug Delivery
This volume provides coverage assisted transdermal and topical delivery by mechanisms of iontophoresis, electroosmosis and electroporation. Other topics discussed are human and clinical studies with iontophoresis, such As Delivery Of Peptides, Proteins And Oligonucleotides, And Other developments
Transporters as Targets for Drugs
Transporters are proteins which span the plasma membrane and regulate the traffic of small molecules in and out of the cell. Transporters play a particularly important role in chemical signalling between neurons in the CNS, where they act to control the concentration of neurotransmitters in the synapse. The majority of transporters which are actively being pursued as targets for drug discovery are CNS located and this reflects the history of the field which began with the tricyclic antidepressants (TCAs) over half a century ago. The use of transporter inhibition to regulate the synaptic concentrations of key neurotransmitters is an established approach in the discovery of psychiatric medications. This volume reviews advances in the field of transporters as targets for drug discovery in the last 10 years. The volume will be of interest to scientists engaged in drug research in the pharmaceutical industry, biotech and academia. Following an overview chapter, seven chapters written by leading experts in their area reflect a range of topics pertinent to the transporter field. General topics include recent advances in the structural biology of transporters and its impact on potential structure based drug design and the design of ligands for Positron Emission Tomography and the importance of molecular imaging in understanding early clinical data. Medicinal chemistry approaches are described outlining the discovery of selective serotonin, noradrenaline and dopamine reuptake inhibitors, current efforts towards the discovery of mixed re-uptake inhibitors with varied ‘flavours’ of monoamine inhibition, advances in the development of inhibitors for the glycine transporter and the discovery of subtype selective EAAT inhibitors. In addition to being an interesting read, the reader will receive a critical overview of progress made in this rapidly developing field.
Handbook of Pharmaceutical Controlled Release Technology
Cambridge Scientific, Inc., MA. Review the design, fabrication, methodology, administration, and classifications of various drug delivery systems, including matrices and membrane-controlled reservoir, bioerodible, and pendant chain systems. Expanded-outline format.
Drug Permeation Enhancement
Conrex Pharmaceutical Corp., Malvern, Pennsylvania. Drugs and the Pharmaceutical Sciences, Volume 62. Text on the fundamental aspects of both physical and chemical enhancement for the transport of peptide and nonpeptide drugs across the skin, mucosa, and cornea. 37 contributors, 32 U.S
Lipospheres in Drug Targets and Delivery: Approaches, Methods, and Applications
Lipospheres in Drug Targets and Delivery: Approaches, Methods, and Applications presents an overview of the most recent applications of lipospheres primarily in the field of medicine, pharmaceutics and biotechnology. Included are chapters on preparation, characterization, delivery (of peptides, proteins, vaccines, nucleic acids) therapeutic applications to different systems and suggestions for further research. Including numerous illustrations, tables and photos, this book provides procedures for specific applications and biological systems and shows lipospheres as a technical solution to various problems associated with controlled release of biochemicals.
Drug Discovery: From Bedside to Wall Street
Everyone expects something from the drug industry. Physicians and patients, investors, regulators and administrators all have an active interest. Everyone wants to know what makes drugs 'work' medically and economically. Why are drugs so expensive? Is it the drug companies or investors who demand high profits? What governs the pharmacoeconomics? Why are so few diseases treatable?
This book opens the windows and doors of the industry telling the story of drug development by using real stories from inside the process.
* Co-written by Graham Lees and Tamas Bartfai who has been involved in the development of drugs taken by more that 20 million people every day
* Opens the windows and doors of the most regulated industry in the world, the pharmaceutical industry
* Tells the story of drug development by using real examples based on current research and events
* Provides an objective, lucid account of the successes and failures, shortcomings and constraints of the pharmaceutical and biotech industries
* Gives insights into the development of new drugs to combat multiple conditions including cancer and pain
* Balanced, unbiased account of how better to translate basic science into drug discovery.
Particulate Interactions in Dry Powder Formulation for Inhalation
Interactions between drug particulates are crucial in determining drug dispersion and deaggregation, and ultimately delivery efficiency. This book combines principles and factors in pharmaceutical powder technology, critically reviews some of the studies carried out in dry powder formulation development, and proposes possible strategies for improving their efficiency. The majority of these principles are applicable to other pharmaceutical solid dosage forms (e.g. tablets and capsules).
Volume 2 discusses the applications and approaches in advanced drug delivery systems, including transdermal, pulmonary, and ocular routes. In addition, it describes the impact of the shift to personalized medicines in the fields of pharmaceutical biotechnology, pharmacogenomics, and nanotechnology.
DELIVERY OF DRUGS BY THE PULMONARY ROUTE - Covers the interaction between the physical chemistry of the formulations and administered particles with the anatomy of the bronchial and alveolar regions
PEDIATRIC AND GERIATRIC PHARMACEUTICS - Addresses the physiological changes, design, and production of formulations for each of these patient populations
BIOEQUIVALENCE EVALUATION - Covers how to measure the bioequivalence of the same drug in quick-release tablet, capsule, or sustained-release form, as well as branded and generic systems
TARGET-ORIENTED DELIVERY SYSTEMS - Explores the challenges of designing delivery systems that target specific sites in the body and cause fewer side effects through interaction with non-diseased tissues.
- الكود:
http://rapidshare.com/files/273294351/tmod_pharm_5edv2.zip
ABC Transporters and Multidrug Resistance
A comprehensive review of the most current scientific research on ABC transporters and multidrug resistance
ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as tumors, to withstand chemicals designed to target and destroy such cells. In MDR, patients who are on medication eventually develop resistance to not only the drug they are taking, but to several
different types of drugs.
- الكود:
http://rapidshare.com/files/266875192/tabc_tran_muldrg.zip
Oral Delivery of Macromolecular Drugs: Barriers, Strategies and Future Trends
This comprehensive volume provides an overview on the description of the structure, the genome, normal tissue expression, physiological aspect, and mechanism of action of the ABC protein. The expert contributors explore the expression, detection, and implications of ABC proteins in hematological malignancies and solid tumors and ABC proteins and pathogenic microorganisms. This volume also explains MDR modulation through inhibition of ABC transporters and the design of inhibitors and mechanism of action. In addition, the book offers essential information on the biological and clinical aspect of multidrug resistance.
-----------------------------------------------------
Oral Delivery of Macromolecular Drugs: Barriers, Strategies and Future Trends
Recent and rapid progress in the field of biotechnology has resulted in an increasing number of novel macromolecular drugs with great promise for further advanced research and clinical application. However, the delivery of these macromolecular drugs by routes other than the parenteral route is difficult. The pipeline of macromolecular drugs derived from biotechnology presents a challenging opportunity to develop practical dosage forms that could be dosed via the oral route. Given this, the successful oral delivery of macromolecular drugs presents an enormous opportunity. Oral Delivery of Macromolecular Drugs will provide an overview of the innovative oral delivery technologies that have demonstrated success in human testing and will go on to cite the challenges, strategies, and future trends that are to be expected.
[ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط]
-----------------------------------
Pharmaceutics: The Science of Dosage Form Design
A comprehensive textbook covering the design of dosage forms and all aspects of drug delivery systems. 'Pharmaceutics' in its broadest sense is the 'art of the apothecary' or, in simple terms, pharmaceutical preparations. It remains a diverse subject in the pharmacy curriculum, encompassing design of drugs, their manufacture, and the elimination of micro-organisms from the products. This books encompasses all those areas and pays particular attention to the design of dosage forms and their manufacture.
- الكود:
http://rapidshare.com/files/259366987/tpharm_sci_dfd2ed.zip
Nanotherapeutics: Drug Delivery Concepts in Nanoscience
An important and exciting aspect in the newly developing field of nanomedicine is the use of nanoparticle drug delivery systems allowing for innovative therapeutic approaches. Due to their small size, these drug delivery systems are promising tools in therapeutic approaches such as selective or targeted drug delivery towards a specific tissue or organ, enhanced drug transport across biological barriers, and intracellular drug delivery.
This timely book provides an overview of possible therapeutic applications. The first part of the book highlights general properties of and phenomena observed with nanoparticles, and the subsequent consequences for applications in drug delivery. The second part focuses on the therapeutic approaches that are possible through the use of nanoparticles, with each chapter discussing a specific disease (e.g. diabetes, cancer, inflammation, etc.) and the relevant therapeutic approaches based on the design of nanoparticulate drug delivery systems. Written in a concise manner, readers will gain an insight into the basics of nanoparticle preparation as well as a more detailed account of what is therapeutically feasible by using nanoparticle approaches.
Contents: General Aspects of Nanotherapeutics: Nanocarriers in Drug Delivery - Design, Manufacture and Physicochemical Properties (C Schmidt & A Lamprecht); Transport Across Biological Barriers (N Nafee et al.); Targeting Approaches (S Cammas-Marion); Disease-Related Approaches by Nanotherapeutics: Nanoscale Cancer Therapeutics (Y Pellequer & A Lamprecht); Nanotherapeutics for Skin Diseases (N Atrux-Tallau et al.); Nanoparticles for Oral Vaccination (J M Irache et al.); Nanoparticles: Therapeutic Approaches for Bacterial Diseases (B Moulari); Nanoparticle Therapy in Parasites Diseases: Possibility and Reality! (M Larabi); Nanocarriers in the Therapy of Inflammatory Disease (A Lamprecht).
- الكود:
http://rapidshare.com/files/244684783/tnanoth_ddt.zip
Physicochemical Principles of Pharmacy, 4th Edition
Physical chemistry is the basis of rational pharmaceutical formulation and processing, and is fundamental to understanding the complexities of drug delivery and drug absorption. This textbook presents the physiochemical principles useful to the modern pharmaceutical scientist and pharmacist.
- الكود:
http://www.megaupload.com/?d=XOVA873Q
Nanotechnology in Drug Delivery
The reader will be introduced to various aspects of the fundamentals of nanotechnology based drug delivery systems and the application of these systems for the delivery of small molecules, proteins, peptides, oligonucleotides and genes. How these systems overcome challenges offered by biological barriers to drug absorption and drug targeting will also be described.
- الكود:
http://rapidshare.com/files/240614492/tnano_dd.zip
Encyclopedia of Pharmaceutical Technology, Volume 20
AAI, Inc., Wilmington, NC. An encyclopedia of pharmaceutical technology, offering a collection of entries on a number of subjects, from drug delivery to process chemistry in the pharmaceutical industry. Lists the contents for all 20 volumes in the set. DNLM: Chemistry, Pharmaceutical-encyclopedias.
- الكود:
http://rapidshare.com/files/235037500/tency_phartechv20.zip
Electrically Assisted Transdermal and Topical Drug Delivery
This volume provides coverage assisted transdermal and topical delivery by mechanisms of iontophoresis, electroosmosis and electroporation. Other topics discussed are human and clinical studies with iontophoresis, such As Delivery Of Peptides, Proteins And Oligonucleotides, And Other developments
- الكود:
http://rapidshare.com/files/233149579/tele_assi_tran_tdd.zip
Transporters as Targets for Drugs
Transporters are proteins which span the plasma membrane and regulate the traffic of small molecules in and out of the cell. Transporters play a particularly important role in chemical signalling between neurons in the CNS, where they act to control the concentration of neurotransmitters in the synapse. The majority of transporters which are actively being pursued as targets for drug discovery are CNS located and this reflects the history of the field which began with the tricyclic antidepressants (TCAs) over half a century ago. The use of transporter inhibition to regulate the synaptic concentrations of key neurotransmitters is an established approach in the discovery of psychiatric medications. This volume reviews advances in the field of transporters as targets for drug discovery in the last 10 years. The volume will be of interest to scientists engaged in drug research in the pharmaceutical industry, biotech and academia. Following an overview chapter, seven chapters written by leading experts in their area reflect a range of topics pertinent to the transporter field. General topics include recent advances in the structural biology of transporters and its impact on potential structure based drug design and the design of ligands for Positron Emission Tomography and the importance of molecular imaging in understanding early clinical data. Medicinal chemistry approaches are described outlining the discovery of selective serotonin, noradrenaline and dopamine reuptake inhibitors, current efforts towards the discovery of mixed re-uptake inhibitors with varied ‘flavours’ of monoamine inhibition, advances in the development of inhibitors for the glycine transporter and the discovery of subtype selective EAAT inhibitors. In addition to being an interesting read, the reader will receive a critical overview of progress made in this rapidly developing field.
- الكود:
http://rapidshare.com/files/230895087/trans_tar_drgt.zip
=
Handbook of Pharmaceutical Controlled Release Technology
Cambridge Scientific, Inc., MA. Review the design, fabrication, methodology, administration, and classifications of various drug delivery systems, including matrices and membrane-controlled reservoir, bioerodible, and pendant chain systems. Expanded-outline format.
- الكود:
http://rapidshare.com/files/212472165/phar_ctrl_rels_tech.zip
Drug Permeation Enhancement
Conrex Pharmaceutical Corp., Malvern, Pennsylvania. Drugs and the Pharmaceutical Sciences, Volume 62. Text on the fundamental aspects of both physical and chemical enhancement for the transport of peptide and nonpeptide drugs across the skin, mucosa, and cornea. 37 contributors, 32 U.S
- الكود:
http://rapidshare.com/files/212444551/tdrg_perm_enh.zip.
=
Lipospheres in Drug Targets and Delivery: Approaches, Methods, and Applications
Lipospheres in Drug Targets and Delivery: Approaches, Methods, and Applications presents an overview of the most recent applications of lipospheres primarily in the field of medicine, pharmaceutics and biotechnology. Included are chapters on preparation, characterization, delivery (of peptides, proteins, vaccines, nucleic acids) therapeutic applications to different systems and suggestions for further research. Including numerous illustrations, tables and photos, this book provides procedures for specific applications and biological systems and shows lipospheres as a technical solution to various problems associated with controlled release of biochemicals.
- الكود:
http://rapidshare.com/files/205914998/tlipo_dt_da.zip
Drug Discovery: From Bedside to Wall Street
Everyone expects something from the drug industry. Physicians and patients, investors, regulators and administrators all have an active interest. Everyone wants to know what makes drugs 'work' medically and economically. Why are drugs so expensive? Is it the drug companies or investors who demand high profits? What governs the pharmacoeconomics? Why are so few diseases treatable?
This book opens the windows and doors of the industry telling the story of drug development by using real stories from inside the process.
* Co-written by Graham Lees and Tamas Bartfai who has been involved in the development of drugs taken by more that 20 million people every day
* Opens the windows and doors of the most regulated industry in the world, the pharmaceutical industry
* Tells the story of drug development by using real examples based on current research and events
* Provides an objective, lucid account of the successes and failures, shortcomings and constraints of the pharmaceutical and biotech industries
* Gives insights into the development of new drugs to combat multiple conditions including cancer and pain
* Balanced, unbiased account of how better to translate basic science into drug discovery.
- الكود:
http://rapidshare.com/files/199626844/dd_bs_ws.zip
Particulate Interactions in Dry Powder Formulation for Inhalation
Interactions between drug particulates are crucial in determining drug dispersion and deaggregation, and ultimately delivery efficiency. This book combines principles and factors in pharmaceutical powder technology, critically reviews some of the studies carried out in dry powder formulation development, and proposes possible strategies for improving their efficiency. The majority of these principles are applicable to other pharmaceutical solid dosage forms (e.g. tablets and capsules).
- الكود:
http://rapidshare.com/files/194785367/tparticu_inter_dp_inhal.zip
